Effect of jinqi tablet on kidney function of diabetic rats
ZHENG Ning
WEI Shi-jin
Abstract：Objective To observe the effect of jinqi tablet on the expression of advanced glycation end products(AGEs), advanced glycation end products receptor(RAGE), nuclear transcription factor(NF)-κBp65 and monocyte chemoattractant protein(MCP)-1 in the kidney of diabetic rats. Methods The level of AGEs, RAGE,NF-κBp65 NF-κBp65 and MCP-1 were determined in the kidney of diabetes group (group DM), diabetes with jinqi tablet(group DD)and control group(group N)at the 20th week. The average plasma glucose(APG) ,triglyceride (TG) ,total cholesterol (TC), endogenous creatinine clearance (Ccr)and urine microal bumin were collected.Results Compared with the group DM, the level of UMA, TG, AGEs, RAGE, NF-κBp65, MCP-1 in group DD was lower, but the Ccr was higher. The pathological changes in group DD were not as significant as that in DM group.Conclusions Jinqi tablet may decrease the renal damage of diabetes. The renal protection of jinqi tablet is not related to the control of blood sugar and it maybe related to the inhibition of AGEs, RAGE, NF-κBp65 and MCP-1.
Keywords：Jinqi tabletDiabetic nephropathyAdvanced glycation end productsReceptor of advanced glycation end productsNuclear transcription factor-κBp65Monocyte chemoattractant protein-1
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)