The applications of chlorderazin in the treatment of patients with acute aortic dissection and hypertension
ZHANG Yu-rong
JIA Rong-bo
ZHANG Xiao-yan
FAN Shu-xia
JI Jin-zhi
Abstract：Objective To explore the efficacy of intravenous chlorderazin for patients with acute aortic dissection and hypertension. Methods Twenty-eight patients with aortic dissection-related hypertension were randomly assigned in sodium nitroprusside group and chlorderazin and sodium nitroprusside group. Hypertension controll within 30 minutes, betaxolol daily dose, and application number of times of analgesic and antiemetic between two groups were observed. Results During 30 minutes treatment, the systolic blood pressure, diostolic blood pressure and heart rate both decreased in sodium nitroprusside group and chlorderazin and sodium nitroprusside group. The degree of decline was more distinct in chlorderazin and sodium nitroprusside group after 15 minutes than that in sodium nitroprusside group. When blood pressure and heart rate were both under control, the continued drug use times were longer in sodium nitroprusside group than that in chlorderazin and sodium nitroprusside group[(74 ± 10)h vs (56 ±12) h, P = 0.030]. Betaxolol daily dose [(65 ± 20)mg vs (46 ± 19) mg, P = 0. 043] and application number of times of analgesic(3.4 ± 1.1 vs 1.0 ± 0.8, P = 0.001) and antiemetic (1.4 ± 0. 8 vs 0.4 ± 0.3, P = 0.005) were significantly more frequent in sodium nitroprusside group than those in chlorderazin and sodium nitroprusside group.Conclusion Intravenous Chlorderazin combined witn Sodium Nitroprusside is effective on treating aortic dissection-related hypertension.
Keywords：Aortic dissectionHypertensionChlorderazinSodium nitroprusside
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)