The mechanism of atorvastatin protection against myocardium and vessel injury in patients with stable angina pectoris undergoing percutancous coronary intervention
CHENG Yu-tong
LI Xiao-feng
SUN Tao
WANG Su
YIN Cheng-qian
QUE Bin
GAO Yu-long
ZHANG Jing-mei
LI Zhi-zhong
Abstract：Objective To compare the effects of pre-treatment with or without atorvastatin on plasm creatine kinase-MB and circulating endothelial cells in patients with stable angina pectoris undergoing percutaneous coronary intervention. Methods One hundred and thirty-four patients with stable angina pectoris were divided into 2 groups.Statin group contained 60 patients who were received 40-80 mg atorvastatin within 12 hours before elective procedure. Non-statin pretreatment group contained 74 patients who had never received any statin therapy before procedure. We measured plasm creatine kinase-MB and lipid before and 24 hours after percutaneous coronary intervention. Circulating endothelial cells were also recorded before and 6 hours after procedure. Results Detection of markers of myocardial injury above the one fold of upper normal limit was significantly lower in the statin group than that in the non-statin group(10.0% vs 23.0%, P ＜ 0.05). Vessel injury by circulating endothelial cells difference determination was detected before and after coronary intervention in the statin group(3.4 ± 2.7)piece/ml and the non-statin group(5.3 ± 2.9)piece/ml ,P ＜ 0.05. There were no significant differences in plasm cholesterol and low desity lipoprotein after procedure between statin [(2.74 ± 0. 47), (1.81 ± 0. 37)mmol/L and non-statin (2.66 ±0.44) ,(1.72±0.13)mmol/L]groups(P ＞0.05). Conclusion Reductin in myocardial injury undergoing coronary intervention in patients with atorvastatin pre-treatment with stable angina pectoris may be related to statin's protective effect on vessel endothelial cells, which is not related to lipid-lowing effect.
Keywords：Angina pectorisAngioplastytransluminalpercutaneous coronaryAtorvastatin
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)