A study on pulse wave velocity and advanced glycation end products in patients with hypertension complicated with cerebral infarction
LI Hong-yan
Mayinuer
MENG Xue-gang
BAI Ting
DANG Hui
WANG Cheng-feng
Abstract：Objective To investigate the effects of pulse wave velocity(PWV) and advanced glycation end products(AGEs) on hypertension complicated with cerebral infarction. Methods Overall 350 subjects were enrolled in this study: 150 patients with primary hypertension without cerebral infarction, 150 patients with primary hypertension complicated with cerebral infarction and 50 aged-matched normotension control (NT) subjects. All of them were detected pulse wave velocity(CFPWV, CRPWV) and the serum concentration of AGEs. Results Compared with primary hypertension without cerebral infarction patients, the CFPWV, CRPWV and AGEs of the patients with primary hypertension complicated with cerebral infarction were significantly higher [CFPWV(12.76±1.25)m/s vs (15.73 ±2.17)m/s], CRPWV(10.79 ±0.95)m/s vs(13.87 ±1.86)m/s and [AGEs(187.42±35.72)mg/L vs (286.53 ±43.29)mg/L]. Furthermore, with the increase of CFPWV, CRPWV and AGEs, the morbidity of primary hypertension complicated cerebral infarction were markedly increased(P=0.015, P = 0.008, P = 0. 027). Logistic analysis showed that CFPWV, CRPWV and AGEs were independently correlated with primary hypertension complicated cerebral infarction respectively. Conclusion The increasing of PWV and AGEs might be involved in the development of primary hypertension complicated with cerebral infarction.
Keywords：HypertensionCerebral infarctionPulse wave velocityAdvanced glycation end products
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)