Effects of iopamidol on kidney function in diabetic patients after coronary angiography or angioplasty
JIANG Dong-ju
SUN Fei
JIA Yu-lin
HU Gao-pin
FU Rong
ZHANG Yan-bo
XUE Bo-wen
Abstract：Objective To determine the effects of the volume of contrast media and risk factors on kidney function in diabetic patients undergoing elective cardiac catheterization or percutaneous coronary intervention (PCI). Methods Totally 148 consecutive diabetic patients undergoing elective cardiac catheterization or PCI were divided into three groups; low dose (＜100 ml), middle dose (100-200 ml) and high dose group (＞200 ml). Serum creatinine and estimated glomerular filtration rate(eGFR) at baseline and after 72 hours of the procedure were measured. The incidence of CIN and the effect of variables on rate of CIN were evaluated. Results There were no significant differences on serum creatinine level and eGFR among groups after cardiac catheterization or PCI. Compared with the preoperative, the levels of serum creatinine in middle dose and high dose group were higher after the procedure [(96.4±21.8)μmol/L vs (87. 5 ±21. 8)μmol/L, (100. 8 ±23. 9) μmol/L vs (88.1 ± 19.9) μmol/L, P＜ 0.05]. The increase of serum creatinine in high dose group were significantly higher than in low dose and middle dose groups. There was no significant difference on eGFR and on the incidence of CIN among groups after cardiac catheterization or PCI. CIN developed more frequently after PCI in female or lower eGFR patients. Conclusion It is safe for some diabetic patients to use large dose of contrast media.
Keywords：Diabetes mellitusIopamidolContrast-induced nephropathy
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)