Clinical significance of plasma thrombomodulin cocentration detection among hemorrhagic disease patients
CONG Lin
ZHANG Wen-juan
XIAO Jing
LI Zhao
YANG Shao-chan
BAO Xue-lin
Abstract：Objective To investigate the relationship between plasma thrombomodulin(TM)concentration and clinical condition in hemorrhagic disease.Methods Enzyme-linked immunoabsorbent assay(ELISA)was a-dopted to detect the plasma TM concentration of 50 patients(25 were allergiC purpura,the other 25 were idiopathicthrombocytopenia purpura)and 40 healthy people in control group.Results The plasma TM concentration of aller-sic purpura group[(32.55±7.48)μg/L]was significantly higher than that of control group[(20.40±7.72)μg/L](P<0.01).The plasma TM concentration of the idiopathic thrombocytopenia purpura(ITP)group was not increasing[(20.29±10.15)μg/L](P>0.05).The plasma TM concentration of the improved allergic purpura group [(20.15±8.02)μg/L]decreased signiflcanfly(P<0.01),while that of the inefficient group[(33.76±8.36)μg/L]and relapse group[(34.06±10.06)μg/L]increased significantly(P<0.01).Conclusions Plasma TM concentration detection helps diagnose two types of hemorrhagic disease.The plasma TM concentration of the allergic purpura is closely related with the clinical situation,therefore it call be used as one of the indexes for learning the state of the disease,observing the curative effect and estimating prognosis.
Keywords：ThrombomdulinAllergic purpuraImmune thrombocytopenia purpura
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)