Effect of epulrestat on urinary N-acetyl-β-D-glucosaminidase,β2-microgiobulin in patients at early stage of diabetic nephropathies
WEI Dai-lin
XU Juan
Abstract：Objective To investigate the effect of epalrestat on urinary N-aeetyl-β-Glucosaminidase(NAG)and β2-Micmglobulin(β2-MG)excretion in patients at early stage of diabetic nephropathies.Methods Sixty patients were divided randomly into two groups;the control group and the treatment group were both treated witll dietary control and oral hypoglycemic drugs or insulin,meanwhile,the treatment group were treated with epalrestat 50 mg three times a day.Results There were no significant difference between control group and treatment group(P>0.05).Urinary NAG/Cr,β2-MG/Cr and mALB/Cr were decreased significantly in epalrestat treatment group after 12 weeks,which were(2.03±0.79)U/mmol vs (3.69±1.35)U/mmol,(0.098±0.070)mg/mmol vs(0.179±0.101)mg/mmol,(6.00±2.20)mg/mmol vs (7.93±2.01)mg/mmol(P<0.05).Condusion Epalrestat can decrease the levels of urinary NAG and β2-MG significantly,which showes that epalrestat can alleviate renal tubular injury.
Keywords：Diabetic nephropathiesEpalrestatN-acetyl-β-D-glueosaminidaseB2一micmglobulin
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)