Effects of edaravone on endothelial cell function in patients with acute cerebral infarction
LI Hong-yan
DI Li-mu-la-ti
HE Xiao-yan
ZU He-re
YANG Li-juan
WANG Ming-yuan
Abstract：Objective To investigate the effeets of edaravone on endothelial cell function in patients with acute cerebral infarction.Methods Two hundred and sixty patients with acute cerebral infarction were randomly divided into treatment group(n=130)and control group(n=130).Treatment group received edaravone injection (30 mg,bid)based on the routine therapy.The Nitric oxide(NO),endothelin-1,plasma soluble thrombomodulin (sTM),yon willebrand factor(vWF),China stroke scale(CSS)score,daily living skills rating scale(ADL)Score and the number of cireulation endothehal cell at the time of 1,3,7,14,21 d after treatment were determined.CSS,ADL SCOre and circulatory endothelial cell number were observed.Results Plasma NO concentration of the control respectively;sTM concentration was(5.67±0.63),(7.64±0.71),(9.85±1.26),(7.89±1.12)μg//L,respec-tively;vWF concentration was(52.47±7.13),(76.59 4-8.17),(86.52±9.16),(68.94±7.52)%respectively;ADL score was(39.99±9.14),(43.64±9.73),(48.36±9.85),(46.78±8.94)points.while the data of the treatment group were(9.85±4.57),(12.57 ±5.39),(15.42±6.73),(13.28±5.68)μg/L;(9.79±0.82),(12.93±1.04),(21.26±3.12),(15.86±2.85)μg/L;(78.95±6.73),(125.61±11.89),(216.75 4-32.85).(178.73±25.83)%;(53.68±9.83),(58.79±11.25),(69.72±13.61),(68.63±11.29)points,re-spectively.Compared with the control group,the serum concentration of NO,sTM,vWF and ADL score of the treat-ment group were significantly inereased.However,the serum concentration of ET-1,CSS score and the number of circulation endothelial cell were markedly decreased.Conclusion Edaravone protects the endothelial cell effectively by decreasing the endothelial cell injury.
Keywords：Cerebral infarctionEdaravoneEndothelial function
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)