Mechanical research of low-dose aminophylline combined with budesonide treating chronic obstructive pulmonary disease with stable phase
YIN Yi-ping
HU Su-ping
GUO Guang-yun
AI Lin
ZHOU Qin
Abstract：Objective To detect the concentration of airway inflammation medium of stabilization chronic obstructive pulmonary disease (COPD) patients treated by low-dose aminophylline combianed with budesonide.Methods Sixty patients were randomly divided into two groups.All the patients were in stanionable phase of severe COPD.Experimental teamwere inhaled budesanide and oral low-dose aminophylline and the control team only inhaled budesonide.The concentration of interleukin(IL)-6,IL-8,tumor necrosis factor(TNF)-a in sputum was detected before and three months after medication.Results After treatment,the concentration of IL-6,IL-8 and TNF-a in sputum had significant difference in two teams.Before and after treatment.the concentration of these inflammtory mediators in sputum had significant difference(P<0.05).Conclusion Low-dosage of aminophylline with budesonide can reduce airway inflammation in stable COPD patients.
Keywords：Pulmonary diseasechronic obstructiveAminophyllineBudesonide
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)