Dezorine versus tramadol for early postoperative analgesia after laparoscopic cholecystectomy
ZENG Zhao-dong
CHENG Ming-hua
LIN Shu-yong
ZHUANG Shao-hui
Abstract：Objective To study the effect of dezocine versus tramadol for postoperative analgesia and side effects after laparoscopic cholecystectomy. Methods Forty patients with postoperative analgesia, American Society of Anesthesiologists I - II class, were randomly divided into two groups. Target controlled infusion of propofol and remifentanly was used to both groups. Both groups were given intermittent cisatracurium. The single intravenous injections of dezocine(0.1 mg/kg)and tramdol(2 mg/kg) were given before 30 min of operation closure. The analgesic efficacy and side effects was assessed by verbal and visual scales at regular intervals after administration. Hemo-dynamic parameters and SpO2 were recorded, before operation, after administration, extubation time, 5, 10, 30, 60 min after extubation. The visual analogue scale(VAS) pain score and OAA/S score of 5, 10, 30, 60 min after extubation were conducted. Adverse reactions with nausea and vomiting and dysthesia after extubation were obtained. Results There was statistical significance of hemodynamic parameters of extubation(P<0.05). Tramadol group (Group T) has the highest incidence of nausea and vomiting. Dezocine group (Group D)has the highest VAS score after recovery (P<0.05). There were no significant changes in respiratory parameters. Conclusion A single 0. 1 mg intravenous injection of dezocine is safe and effective for postoperative pain after laparoscopic cholecystectomy.
Keywords：DezocineAnalgesiaTramadol
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)