Relation between C-reactive protein level and carotid intimae-media thickness in patients with coronary artery disease and glucose metabolism
SONG Li-li
LI Yu-ling
ZHANG Wei
Abstract：Objective To explore the relation between high sensitive C-reactive protein(hs-CRP)level,and carotid intimae-media thickness in Chinese patients with coronary artery disease(CAD).Methods One hundred and forty eisht patients with coronary heart diseases(CHD),who were Weifang Hanting People's Hospital patients from April 2008 to January 2010 met the diagnostic criteria for ischemic heart disease.The participants were divided into 3 groups:normal glucose tolerance(NGT)group,impaired glucose regulation(IGR)group and diabetes mellitus(DM)group.The coranory anglographic score and clinical data were recorded,hs-CRP,TC,TG,HDL-C,LDL-C and FPG were detected.Carotid intimat-media thickness were measured by Color Doppler ulirasonography. Results CHD patients with IGR and T2DM often had there branohes disease.The corenary angiographic score and the severity of coronary disease of CHD pafients with IGR and T2DM were signitlcanfly higher than those of patients without diabetes[(27.5±12.6),(33.8±11.2),P<0.01 ].The carotid IMT and the incidence of carotid plaque were higher in CHD patients with IGR and T2DM[73.6%vs 86.7%vs 56.2%,(1.2±0.2)mmvs(1.4±0.1)mm vs(1.0±0.2)mm,P<0.05].The CRP levels in normal glucose tolerance(NGT)group,impaired glucose regulation(IGR)group and diabetes mellitus(DM)group were increased[(42.0±58.5)mg/L.(74.3±86.2)mg/L,(116.5±115.6)mg/L,P<0.01].The serum hs-CRP level was positively correlated with IMT(r=0.308,P<0.05).Conclusion The serum hs-CRP and the carotid IMT might be regard as a predicative marker for the severity of coronary heart disease.
Keywords：Coronary arteriosclerosisGlucose metabolismC-reactive proteinCarotid intimaemedia thickness
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)