Stability of cefoxitin sodium for injection mixed with ornidazole and sodium chloride injection
ZHANG Jing-yang
ZHENG Fang
ZHU Xue-song
Abstract：Objective To study the stability of cefoxitin sodium for injection and omidazole and sodium chloride injection at ambient temperature, in order to provide a scientific basis for rational use of drug in clinical practice. Methods The changes of the contents of cefoxitin and ornidazole were determined simultaneously by RPHPLC-DAD, and the changes of appearance, pH values were observed within 6 hours. Results The detection wave lengths were 318 nm, 237 nm for ornidazole and cefoxitin, the calibration equation was Y0 = 0. 7444X0 + 3.0667 (r =0.9998, n = 6) for ornidazole and Yce = 0. 6549Xce + 6.2667 ( r = 0. 9996, n = 6) for cefoxitin. No significant changes were noted in the contents, appearance and pH value for the mixed solution within 6 hours. Conclusion Cefoxitin sodium for injection can be mixed with ornidazole and sodium chloride injection at ambient temperature within 6 hours.
Keywords：OrnidazoleCefoxitinChromatographyhigh pressure liquidDrug incompatibilityDrug stability
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)