Study of plasma hypoxia-inducible factor 1 alpha and vascular endothelial growth factor expression in patients with non-Hodgkin's lymphoma
HOU Yun-hua
ZHANG Yong-li
MAI Yu-jie
Li Ning-ning
Abstract：Objective To examine the expression of plasma hypoxia-inducible factor 1 alpha (HIF-1 α),vascular endothelial growth factor (VEGF) and microvessel density (MVD) of patients with NHL. Methods Totally 28 cases in NHL group( group A) and 27 cases in control one( group B) were enrolled. We examined the expression of HIF-1α, VEGF and MVD in tissue samples with immunohistochemical stain of two groups respectively.Results The levels of HIF-1α, VEGF and MVD in the two groups respectively with significant statistical difference. Conclusions The levels of HIF-1 α, VEGF and MVD in patients with NHL is higher than that of in lymphadenitis. It's possible that HIF-1α can promote MVD via adjusting VEGF level.
Keywords：Lymphomanon-hodgkinHypoxia-inducible factor 1 alphaEndothelial growth factor
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)