Effect of new quadruple chemotherapy and traditional triple therapy for helicobacter pylori
XU Pei-xian
FENG Xiao-ling
Abstract：Objective To compare the effect of new quadruple chemotherapy and traditional triple therapy for helicobacter pylori. Methods Totally 120 ulcer patients which being detected positive on 14C-Urea Breath Test (14C-UBT) are divided into 2 groups. The patients of treatment group were treated by omeprazole + bismuth +acheomycin + tinidazole and the control groups were treated with omeprazole + clarithromycin + amoxicillin. The patients of two groups were all made electronic gastroscope, histology and 14C-Urea Breath Test within 1 week after the course of treatment has ended. Results The positive-nategive rate on 14C-UBT of first time treated patients is 95.1%, the repeated treated patients was 89.5% and the total positive-nategive rate was 93. 3% on 14C-UBT in the treatment group, while the positive-nategive rate on 14C-UBT was 77.5%, 55.0% and 70.0% in the control group. The ulcer recovery rate in the patients of treatment group was 86.7% while control group was 71.7%. The ulcer recovery rate and the positive-nategive rate on 14C-UBT of first time treated, repeated treated and the total in the patients of treatment group were higher than the control group all (P ＜ 0.05). Conclusions The positive-nategive rate on 14C-UBT and the ulcer recovery rate of new quadruple chemotherapy are higher than that of traditional triple therapy.
Keywords：Helicobacter pyloriNew quadruple chemotherapyTraditional triple therapy14C-urea breath testPositive to nategive rate
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)