Expressive activities of nm23 and the association with micrometastases in rib marrow of non-small cell lung cancer
LU Zhu-ming
WU Shuo-yun
LI Hong
YE Min
ZHOU Wei
PANG Wen-guang
Abstract：Objective To evaluate the clinical significance and the relationship of the expression of nm23 and micrometastases in bone marrow with non-small-cell lung cancer (NSCLC). Methods Immunohistochemical staining was used to detect the nm23 expression in the tumor tissue and micrometastases in the rib bone marrow.Results For all the 79 patients, expression of nm23 was positive in 47 ( 59.5 % ) while negative in 32 (40.5%)cases and micrometastasis were detected in 37 (46.8%) while negative in 42 ( 53.2% ) cases. Expression of nm23 positive in 17 ( 36.2% ) cases was detected micrometastases in the rib bone marrow and 30( 71.4% ) cases was not detected( P＜0.05). Conclusions The micrometastases in bone marrow are closely related to nm23 in patients with NSCLC. Therefore, Combined detection of expression of nm23 and micrometastases in bone marrow plays a key role in prediction and prognosis of NSCLC.
Keywords：Carcinomanon-small cell lungBone marrow micrometastasesNm23
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)