Effects of short-term rosuvastatin therapy on high sensitive C-reactive protein, von wi1lebrand factor and endothelium dependent vasodilatation function in patients with acute coronary syndrome
LIU Yu
WANG Juan
YANG Jun
Abstract：Objective To study the effects of short-term rosuvastatin therapy on high sensitive C-reactive protein (hs-CRP), von Willebrand factor(vWF) and endothelium dependent vasodilatation function in patients with acute coronary syndrome(ACS). Methods Totally 62 patients with ACS were randomly divided into the statin group (n =31 ) and control group (n =31 ). The patients in statin group were treated with Rosuvastain 20 mg/day besides conventional therapy; the patients in control group were treated only with conventional therapy and placebo.The course of therapy was 8 weeks. Plasma levels of hs-CRP and vWF, endothelium dependent vasodilatation function were measured before and after treatment. Results The plasma levels of hs-CRP and vWF in statin group were decreased significantly (P ＜0.01 ), also endothelium dependent vasodilatation function were improved than the patients in control group after 8 weeks. Conclusion It is suggested that short-term therapy with rosuvastatin in patients with ACS could reduces the levels of hs-CRP and vWF and improve the function of endothelium dependent vasodilatation, thus it promotes the stabilization of atheroselerotic plaque.
Keywords：RosuvastatinAcute coronary syndromeC-reactive proteinVon willebrand factorVasodilatation
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)