The treatment of acute pancreatitis with Shenxiong injection combined with aescinate

ZOU Jin-lin; YUAN Qi-wen; BIAN Zhuang

doi:10.3760/cma.j.issn.1673-4777.2011.02.032

Abstract：Objective To study clinical effects of Shenxiong injection and aescinate in the treatment of acute pancreatitis,and to understand the effect of Shenxiong injection and aescinate on the concentration of plasma endothelin(ET) in patients with acute pancreatitis(AP). Methods Eighty-seven cases of AP patients were randomly divided into group A(20 cases) and the control group B(33) and group C(34). A group had conventional therapy,B group had the conventional treatment plus Shenxiong injection and C group had conventional treatment plus Shenxiong injection and aescinate. The plasma concentrations of ET were mensurated with radiation immunoassay(RIA). Results The pain disappearance time had no significant difference(P ＞0.05) among the three groups.The time of abdominal tenderness disappearance,intestinal function recovery,hematuria amylase recovery,imaging recovery and average hospitalization were shorter in B group and in C group than those in control group(A group)(P ＜0.05). The plasma ET concentrations after treatment were significantly lower than that before treatment in group B and C(P＜0.05). Conclusions The therapy based on the conventional treatment combined with Shenxiong injection and aescinate has good curative effect in patients with acute pancreatitis.