Clinical efficacy of tiopronin in protecting liver function in tuberculous patients concomitant with hepatitis B
ZHANG Xue-feng
ZOU Gong-min
QIN Zhao-ke
YANG Qin
Abstract：Objective To study the proctective effect of liver function with tiopronin in tuberculousis patients with hepatitis B. Methods Pulmonary tuberculosis patients with hepatatis B were randomly divided into 2 groups: tiopronin treatment group and normal treatment group. Two groups were given short-course anti-tuberculous treatment. The abnormalisise of hepatic function,clinical manifestations and the onset time of abnormalisise of hepatic function and clinical manifestations were compared and analyzed. Results There was a significant improvement in the abnormalisise of hepatic function and clinical manifestations in tiopronin treatment group (P ＜ 0.05).Conclusions Tiopronin can reduce the liver adverse reactions,protect liver funtions and improve the toxic symptoms. It will play a positive role in adjuvant therapy of short-couse chemotherapy of pulmonary tuberculousis patients with hepatitis B.
Keywords：TioproninTuberculosispulmonaryHepatitis B virusAlanine transaminase
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)