Clinical significance of the serum levels of homocysteine,high sensitive C-reaction protein and tumor necrosis factor-α in patients with acute cerebral infarction
XI Xiang-yin
Abstract：Objective To investigate the clinical significance of the serum levels of homocysteine (Hcy),high sensitive C-reaction protein (hs-CRP) and tumor necrosis factor (TNF)-αt in patients with acute cerebral infarction(ACI). Methods One hundred patients with ACI were enrolled. They were divided into different groups according to the size of infarction and clinical neurologic impairment degree score. Hcy and TNF-αt concentrations were detected by enzyme-linked immunosorbent assay (ELISA),The serum hs-CRP level was detected by immunoturbidimctry. Results The serum Hcy,hs-CRP and TNF-α levels in ACI Patients with ACI were significantly higher than those in the healthy subjects (P＜0.05). The serum levels of Hcy,hs-CRP and TNF-α increased with the volume of infarction and the differences between the groups were significant (all P＜0.05). The serum levels of Hcy,hs-CRP and TNF-αincreased with the clinical neurologic impairment degree score and the differences between the groups were significant (P＜0.05). Conclusions The serum levels of Hcy,hs-CRP and TNF-αare significantly elevated in the patients with ACI. The serum level of Hcy,hs-CRP and TNF-αare increased closely with the volume of infarction and the clinical neurologic impairment degree score,which suggests that Hcy,hs-CRP and TNF-α may play an important role in the Pathogenesis of ACI,and probalbly be a prognostic factor of ACI.
Keywords：Brain infarctionCysteineC-reactive proteinTumor necrosis factor-alphaEnzymelinked immunoabsorbent assay
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)