Plasma brain natriuretic peptide level in differentiating etiology of dyspnea in emergency patients
LIU Shu-yuan
WANG Li-qiu
LIN Zhu-sen
HU Yuan-qin
LI Tian-jie
Abstract：Objective To explore the value of plasma brain natriuretic peptide (BNP)level in differentiating etiology of dyspnea in emergency patients. Methods The plasma BNP levels in 155 emergency patients with dyspnea were assayed. The correlation between BNP levels and left ventricular ejection fraction(LVEF) and E/A respectively. Sensitivity and specificity in differentiating etiology of dyspnea were calculated based on different levels of BNP. Results The BNP levels in cardiogenic dyspnea group were negatively correlated with LVEF and E/A respectively (P ＜ 0.01). They were also significantly higher than those in noncardiogenic dyspnea group (P ＜ 0.01).The sensitivity in diagnosing cardiogenic dyspnea at different critical BNP levels (100 ng/L,300 ng/L,500 ng/L)was 100.0%,92.2%,80.0%,and the specificity was 73.9%,90. 8%,100.0% respectively. Conclusions Plasma BNP level has significant value in preliminarily differentiating etiology of patients with dyspnea. Lower BNP level (＜ 100 ng/L) is helpful in excluding cardiogenic dyspnea and higher BNP level (＞500 ng/L) is helpful in confirming cardiogenic dyspnea. However,BNP level between 100 ～ 500 ng/L isdeficient in confirming and excluding cardiogenic dyspnea.
Keywords：DyspneaNatriuretic peptidebrainDiagnosisdifferential
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)