Clinical effect of ulinastatin in prevention of contrast induced renal injury in elderly patients with coronary heart disease
ZENG Xin-yan
TANG Hui-fang
Abstract：Objective To investigate the effect of ulinastatin on contrast-induced nephropathyin patients with coronary heart disease. Methods Eighty-seven patients of or above 65 with coronary heart disease from March 2007 to May 2008 were randomly divided into control group and ulinastatin(UTI)group: control group had 44 cases of normal hydration and UTI group had 43 cases. The parameters of renal functions were measured and compared 48hours and 5 days after contrast administration,including serum urea nitrogen and creatinine and creatinine clearance rate and urineβ2-microglobulin and urine N-acety l-β-glucosaminidase (NAG),Kidney damage factor (KIM-1),free water clearance (CH2O) and contrast medium nephroma. Results Forty-eight hours after application of contrast agent,serum BUN,Cr and urine β2-MG,NAG,KIM-1,CH2O in the two groups were significantly increased and CrCl declined (P ＜ 0.05),but these indexes in observation group were significantly lower than those in the control group (P ＜ 0.05). Contrast agent nephropathy occurred in 8 patients (18.2%) in control group,while 3 occurred in observation group patients (6.9%),(P ＜ 0.05). Conclusion Ulinastatin has preventive effect on contrast induced nephropathy in patients with coronary heart disease.
Keywords：Coronary artery diseaseElderlyContrast MediaNephrsisUlinastatin
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)