The effects of ambroxol hydrochloride on serum Interleukin-8, Interleukin-18 in patients with acute exacerbation of chronic obstructive lung disease
GAO Zhong-hong
LIU Ya-nan
Abstract：Objective To study the effect of ambroxo1 on interleukin (IL)-8, IL-18 in chronic obstructive pulmonary disease (COPD). Methods Eighty-two patients with acute exacerbation of chsonic obstructive pulmonary disease (AECOPD) between 2007 and 2009 were enrolled, according to the guidelines for COPD treatment. All patients were in acute period with middle level lung dysfunction. They were divided into two groups: conventional therapy (n = 32 ), conventional and interferential therapy ( n = 50). The treatment group was given conventional therapy plus ambroxol for 14 days. The levels of IL-8,IL-18 in serum before-and-after therapy in two groups were observed. Results The level of IL-8, IL-18 in serum of two groups after therapy was lower than that before therapy (P ＜0.05). In the group of conventional plus interferential theraphy,the level of IL-8 ,IL-18 in serum after therapy were lower than that of conventional therapy ( P ＜ 0.05). Conclusion Ambroxol can inhibit the release of IL-8,IL-18 in serum of COPD patients.
Keywords：Pulmonary diseasechronic obstructiveAmbroxolInterleukin-8Interleukin-18
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)