Research of combined application of lipitor, aspirin and clopidogrel after carotid artery stenting in patients with transient ischemic attack
YIN Ji-jun
ZHU Chuan-xian
WANG Xin-qiang
Abstract：Objective To observe the efficacy and safety of combined therapy with lipitor, aspirin and clopidogrel after carotid artery stenting in patients with the carotid system transient ischemic attack (TIA). Methods Forty-two cases of carotid artery stenting of the carotid arterial system TIA patients were randomly divided into three groups with 14 cases in each group: the first group with clopidogrel 75 mg/d for 3 months; the second group with clopidogrel 75 mg/d for 6 months and the third group with clopidogrel 75 mg/d for 12 months. Three groups of patients had aspirin 100 mg/d, lipitor 20mg/qn. At 1,3,6 and 12 months after stenting, carotid artery ultrasound,transcranial doppler or DSA was done and major cerebrovascular disease ( cerebral vascular death, cerebral embolism) were then compared. The occurrence rate of major cerebralvascular events and adverse reactions were observed. Results In the first group,1 case had cerebral embolism with the narrow part,3 cases had restenosis. Cerebral embolism was not observed in the second group and the third group. 1 patients had upper gastrointestinal bleeding in the third group. 1 patients had mild gastrointestinal bleeding. 3 cases had skin ecchymosis and bleeding gums.There was no liver function and muscle damage. Conclusions Long-term combined administration of lipitor,aspirin and clopidogrel is safe and effective in carotid artery stenting of TIA. It helps reduce the occurrence of cerebralvascular events after carotid artery stenting operation. But the bleeding complication with the drug also correspondingly increases.
Keywords：Ischemic attacktransientAtorvastatinAspirinClopidogrelCarotid arteriesStents
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)