Relation among serum levels of homocysteine, folic acid, vitamin B12 and coronary artery lesions
LIU Yan
HE Jian-xun
XU Pin-ying
SUN Jian-wu
LI Feng-mei
Abstract：Objective To investigate the relation among serum homocysteine (HCY), folic acid (FA),vitamin B12 and the extent of coronary artery lesion in patients with coronary heart disease (CHD). Methods The study included 68 CHD patients and 30 non-CHD patients diagnosed according to the coronary angiography findings.Venous blood samples were taken in all subjects and analyzed for HCY, FA, VitB12. Results The concentration of HCY in CHD group was significantly higher than that in non-CHD control group ( P ＜0. 01 ). HCY and FA or VitB12 were remarkably negative related(r = - 0. 678, r = - 0. 6719, P ＜ 0. 05 ) in single-vessel group; while in multi-vessel group HCY and FA or VitB12 are remarkably negative related(r= -0.7619, r = -0.7894, P＜0. 01). Conclusions The high level of HCY is closely related to the extent of coronary artery lesion. Serum FA and VitB12 play an important role in the regulation of serum HCY level.
Keywords：Coronary diseaseHomocysteineFolic acidVitamin B12
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)