Anti-proliferation and endothelial protecting effect of triptolide-eluting stent on porcine model with coronary Restenosis
MA Han-ying
ZHAO Tie-fu
GE Hai-long
SHI Hong-zhi
HAN Hong-ya
ZHOU Yu-jie
Abstract：Objective To investigate the anti-proliferation and endothelial protecting effect of triptolide-eluting stent. Methods Experimental porcines were divided into 2 groups with 8 porcines in each group:triptolide-eluting stent group and rapamycine-eluting stent group.Morphometric,histopathologic,RIA and biochemical staining analysis were compared between the two groups 12 weeks after stenting in porcine model of coronary restenosis. Results The neointimal areas of triptolide-eluting stents(0.74±0.05)mm2 were similar to rapamycine-eluting stents(0.70±0.04)mm2(P ＞0.05).At 4 weeks,plasma endothelin-1 was lower in triptolide group(76.1±20.5)ng/L than that in rapamycine group(88.3±17.9)ng/L.No evidence of toxic effects had been found in the experimental animals related to triptolide-eluting stent. Conclusions Triptolide-eluting stent may inhibit neointimal prolieration during 12 weeks.Triptolide probably takes part in protecting endothelial function.
Keywords：TriptolideCoronary restenosisEndothelinsStents
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)