Effect of lappaconitine on immunoglobulin levels of patients with upper abdominal surgery
YAN Zong-ting
ZHANG Hong-mei
ZHONG Xiao-yan
Abstract：Objective To detect lappaconitine(LA) effect on the levels of IgA, IgM, IgG in upper abdominal surgery patients. Methods Thirty-six patients with upper abdominal surgery were randomized in to 3 groups with 12 in each group( LA group, the tramadol group and the placebo group). Patients in LA group and tramadol group received intravenous drop of LA 8 mg and tramadol 100 mg in 30 min, then received background pump supply of LA 0.28 mg/ml or tramadol 8 mg/ml, and PCA was conducted postoperatively. Peripheral venous blood was taken (30 min before anesthesia, immdiately after the hemorrhoid operation and at postoperative 24th 48th h)for IgA,IgM and IgG examination. Results IgA level in the placebo group was much lower at postoperative 48 h than that in the LA group(P＜0.05);IgM level was much lower in placebo group and tramadol group at 24 h than that in LA group(P＜0.05). The IgG level immediately after operation and at the postoperative 24th h in placebo group was much lower than that in LA group (P＜0.05). Conclusion Lappaconitine can stabilize IgA, IgM and IgG levels after upper abdominal surgery.
Keywords：Upper abdominalSurgeryLappaconitine
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)