Clinical observation of the effect of compound glycyrrhizin and interferon α-2b in treating chronic hepatitis B
ZHANG Ping
YAO Lü-feng
ZHANG Yue-ying
Abstract：Objective To investigate the clinical effect of compound glycyrrhizin combined with interferon α-2b on chronic hepatitis B (CHB). Methods Seventy-six CHB patients were randomly assigned into treatment group (39 cases) and control group (37 cases). Treatment group were given compound glycyrrhizin (100 ml, 80 ml and 60 ml for 4 weeks respectively) combined with interferonα-2b (once a day for 4 weeks, and then 500 MU interferon a every day for 32 weeks) and control group were given the same dose of interferonα-2b. All patients were treated for 36 weeks and then were followed up for 24 weeks. Results By the end of therapeutic course, the rates of negative conversion of HBsAg, HBeAg, HBV-DNA and the rates of positive conversion of HbeAb in the experimental group were much higher those in control. By the end of follow-up, the ALT recovery rates, the rates of negative conversion of HBeAg and HBV-DNA and the rates of positive conversion of HbeAb in the experimental group have statistically higher than those in control. Conclusion The efficacy of compound glycyrrhizin combined with interferon α-2b treatment for CHB patients is high.
Keywords：Chronic hepatitis BInterferonCompound glycyrrhizin
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)