Clinical observation of chemotherapy with docetaxel and oxaliplatin and concurrent radiotheapy in local advanced non-small-cell lung cancer
LI Ying
LIU Jian-min
SHEN Tai-chun
WANG Xiu-ling
JING Feng-ying
Abstract：Objective To observe the efficacy and side effects of docetaxel and oxaliplatin based chemotherapy and concurrent radiotherapy in local advanced non-small cell lung cancer(NSCLC). Methods Seventy-two patients with local advanced non-small cell lung cancer were divided into two groups randomly. Thirty-five cases in the treatment group received 2 cycles of docetaxel 75 mg/m2 on day 1 and oxaliplatin 130 mg/m2 on day 2 with 21 days for 1 cycle. And followed by three-dimensional conformal radiotherapy(3D-CRT)(2 Gy/f, 5 f/w, totally 60-70 Gy). Thirty-seven cases in the control group were treated by 3D-CRT only. The clinical response was assessed after treatment. Results Overall response rate, 1 and 2-year survival rates and average tumor progress time were higher in the concurrent chemoradiotherapy group( 80.0% ,68.6% ,42.9% and 10.2 months respectively) than those in the radiotherapy alone group (56. 8%, 40.5%, 18.9% and 4. 5 months respectively). Conclusions Docetaxel and oxaliplatin based chemotherapy and concurrent radiotherapy in local advanced non-small cell lung cancer can improve short term response rate, survival rates and average tumor progress time. The regiment is well tolerable and effective.
Keywords：CarcinomaNon-small-cell lungConcurrent radio-chemotherapyDocetaxelOxaliplatin
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)