Clinical observation of the effect of compound Danshen injection on aspirin resistance
CHENG Gong
QIAO Yuan
YAO Xiao-wei
YANG Jun-lu
SHOU Xi-ling
Abstract：Objective To investigate the effects of the compound Danshen injection and combined with aspirin on platelet aggregation ratio in the patients with aspirin resistance. Methods A total of 52 patients with aspirin resistance and semiresistance were screened for the observation and were randomly assigned to two groups. The first group was administered intravenously with the compound Danshen combined with aspirin, the other group was treated intravenously with compound Danshen only. Two weeks later, all were retested the platelet aggregation ratio. Results The platelet aggregation ratio induced by ADP and AA was (73.8 ±3.9)%, (68.6±3.7)%, (12.7±2.2)% , (18.5 ±2. 3)% ; the platelet aggregation ratio of patients treated with compound Danshen injection and combined with aspirin was (74.2 ±3.8)%, (61.3 ±4.2)%, (23. 1 ±2.6)%, (12.7 ±2.2)%. Both of them had a significantly decrease in various indexes (P <0.05 or P <0.01) ; moreover, the platelet aggregation ratio of patients treated with compound Danshen injection and combined with aspirin has a lower level than that of patients treated with compound Danshen only (P <0. 05 ) . Conclusions Both compound Danshen injection alone and combination with aspirin therapy may reduce platelet aggregation in patients with aspirin resistance.
Keywords：Coronary artery diseaseAspirinDanshen injection
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)