Effects of atorvastatin on serumsoluble P-selectin level in acute coronary syndrome
XU Jia-jun
LAI Jin-shi
Abstract：Objective To study the effects of Atorvastatin on serumsoluble P-selectin level in Acute Coronary Syndrome. Methods One huanred and twenty Acute coronary syndrome were randomly divided into three groups including atorvastatin in high dosage group(40 mg, n = 40) ,atorvastatin in low dosage group( 10 mg, n =40) and control group(n =40). Patients with atorvastatin were taked orally per day for one weeks. Before and after treated one week, the concentrations of P-selectin were measured by ELISA. Results Compared with before routine treatment, the level of P-selectin has a significantly decreese. Compared with before atorvastatin treatment, the level of P-selectin has a significantly decrease after one week. Compared with routine treatment group, atorvastatin has a significally decrease the level of P-selectin in one week and the level of P-selectin of atorvastatin in high dosage group has more significantly decreese than low dosage group (P <0. 05). Conclusions Atorvastatin can decrease the level of P-selectin in acute coronary syndrome.
Keywords：Coronary diseaseAtorvastatinP-selectin
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)