Effects of nicardipine combined with esmolol on cardiovascular response to tracheal extubation in elderly patients with hypertension
ZHU Cai-fang
YANG Yin-wei
Abstract：Objective To observe the effect of the combined administration of nicardipine and esmolol on cardiovascular response to tracheal extubation in patients with hypertension. Methods Thirty patients were randomly divided into 3 groups: Group Ⅰ , control group; Group Ⅱ , nicardipine group; and Group Ⅲ, studied group. Before extubation, the patients were pretreated with a intravenous infusion of physiological saline in Group Ⅰ , nicardipine 10 μg/kg in Group Ⅱ, and esmolol 1 mg/kg and nicardipine 10 μg/kg in Group Ⅲ. Heart rate( HR) , mean systemic arterial pressure( MAP) of all patients were separately recorded premedication, before extubation, at extubation, 5 mins and 10 mins after extubation. Results Patients in Group Ⅰ had obvious cardiovascular response,especially at the moment of extubation. HR, SBP and MAP were greatly higher than the basic value. (P <0. 01).Before extubation, at extubation HR was higher than the basic value in Group Ⅱ (P<0.05). Before extubation, at extubation SBP was even lower than the basic value in Group Ⅲ (P < 0. 01). HR was lower than the basic value.The whole observation period extubation MAP were lower than the basic value in Group Ⅲ. Conclusion The combinative administration of nicardipine and esmolol can effectively control the cardiovascular response to extubation among the hypertensive patients and without obvious side effects.
Keywords：HypertentionNicardipineEsmololIntubationintratracheal
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)