Effect of pioglitazone unietd irbesartan on hypertension with left ventricular hypertrophy and brain natriuretic peptide
XIONG Pan
LIU Kun
DONG Ai-zhi
Abstract：Objective To explore the effect of Pioglitazone on hypertension with left ventricular hypertrophy and brain natriuretic peptide. Methods Eighty cases of hypertension patients were selected and randomly divided into pioglitazone group and the conventional treatment group. Conventional treatment group were treated with irbesartan (150 mg/d) ; pioglitazone group were treated with irbesartan ( 150 mg/d) and pioglitazone ( 15 mg/d). Both treatment lasted for 6 months. The changes of the levels of left ventricular mass index (LVMI) , serum brain natriuretic peptide(BNP) were compared between two groups before and after treatment. Results The levels of LVMI,serum BNP decreased after treatment in the pioglitazone group and the conventional treatment group. There were significant differences before and after treatment (P < 0. 05). After treatment, the levels of LVMI, serum BNP decreased significantly in the pioglitazone group( P < 0.05). Conclusion Pioglitazone can reverse left ventricular hypertrophy and reduce serum concentration of brain natriuretic peptide.
Keywords：HypertensionPioglitazoneIrbesartanLeft ventricular hypertrophyBrain natriuretic peptide
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)