Improvement of left ventricular function by intracoronary transplantation of autologous bone marrow stem cell in patients with acute myocardial infarction

YIN Zuo-min; LI Chang-jiang; WANG Yan; LIU Wei-sheng; TENG Jun

doi:10.3760/cma.j.issn.1673-4777.2010.09.004

Abstract：Objective To investigate the effect of intracoronary transplantation of autologous bone marrow mesenchymal stem cell on left ventricular function in patients with acute myocardial infarction. Methods After successful percutaneous coronary intervention( PCI) for acute myocardial infarction, 38 patients were randomly assigned to either a control group ( n = 20) that received optimum postinfarction medical treatment, or a bone-marrow-cell group(n = 18) that received optimum medical treatment and intracoronary transfer of autologous bone-marrow cells 14 days after PCI. Data about myocardial perfusion imaging and left ventricular ejection fraction ( LVEF) were obtained by SPECT and echocardiogram, respectively, before and at 6 months' follow-up. Results There was no significant difference between the two groups in myocardial perfusion imaging and left ventricular ejection fraction befor intracoronary transplantation of autologous bone marrow stem cell(2. 1 ±0. 1 vs 2. 2±0. 2, P = 0. 76 and 0. 45 ±0.13 vs 0.41 ±0.22, P = 0. 56). After 6 months, SPECT myocardial perfusion was better in treated patients(1.5 ±0.2 vs 2.3±0.4, P=0.04) and LVEF improved significantly(0.55 ±0. 12 vs 0. 44 ±0.24, P=0.03) compared with the control. The incidence of heart failure in patients accepted inracoronary transplantation of autologous bone marrow stem cell was significantly decreased(5.5% vs 35.0% , P = 0. 03), though there was no significant difference in re-infarcion, re-myocardial perfusion and death. Conclusion The left ventricular function can be improved and the heart failure can be decreased by intracoronary transplantation of autologous bone marrow stem cell in patients with acute myocardial infarction.