The study of biphsic insulin premixede aspart 30 versus human insulin 30 in controlling glycemia of sulphanylureas failed type 2 diabetes
QU Jian-chang
ZHU Kai-si
WANG Li-sha
WANG Tong
LI Li
Abstract：Objective To compare the efficiency and security between biphasic insulin 30(30% fast acting and 70% protamine crystallized insulin as part, BIAsp30) and premixed human insulin 30(30% regular insulin and 70% NPH insulin, BHI 30) in sulfonylureas failed type 2 diabetes. Methods Eighty-six cases of sulfonylureas failed type 2 diabetes were randomly divided into two groups. Glycemic and HbA1c after the treatment were com-pared. Results Totally 13 and 26 weeks after treatment, 7 time points of blood glucose were all significantly de-creased in two groups compared with baselines (P < 0.05). Postprandial blood glucose decreased more in biphasic insulin aspart group. HbA1c decreased from ( 11.32 ± 1. 35)% (baseline) to (7.87 ±0.22)% (13th week) and (6. 19 ±0.36)% (26 th week) in biphasic insulin aspart group. HbA,c in premixed human insulin group de-creased from (11.07 ±1.52)% (baseline) to (8.53 ±0.27)% (13 th week) and (7. 12 ±0. 15)% (26 th week) (P<0.05). Hypoglycemia was observed in only 8% patients taking biphasic insulin as part compared with 27% patients taking premixed insulin (P < 0.05). Satisfaction and compliance were higher in patients taking bipha-sic insulin as part compared with premixed insulin group (P < 0. 01 or P < 0. 05). Conclusion In diabetes pa-tients with poor glycemic control by oral sulfonylureas, early use of biphasic insulin aspart significantly improves gly-caemic control.
Keywords：Diabetes mellitustype 2Biphsic insulin aspartPremixed human insulin
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)