Clinical research of lumbrukinase capsule on cerebral hemodynamics in patients with acute infarction
ZHANG Jian-bin
LU Liang-yan
WANG Su-fang
WU Li-li
Abstract：Objective To observe and study the clinical efficacy of lumbrukinase capsule and its effect on cerebra hemodynamics in patients with acute infarction. Methods Totally 88 patients were enrolled. This clinical trial was randomly double-blind and parallel controlled. The patients with acute infarction were divided into two groups. All patients recieved same basic treatment; The treatment goup trented by oral administration of lumbruki-nase capsule then scoring the condition of neural functional deficits before and after the treatment; meanwhile the ce-rebrovascular dynamics index (CVDI) of the patients were measured. Results ①The neural functional deficits of patients in trial group tended to be repaired. The effective rate( ER) was 90. 5% ,but the control group's ER was 77.5%. ②The total cerebral blood flow and velocityin the focal side of brain after the treatment in the treatment group showed a statistically significant increase,compared with those before the treatment(P<0.05),and even with the co up(P<0.05). And the cerebral vascular resistance(R) and critical pressure showned a statistically significant decrease(P<0.05). Conclusions These results reveal that the lumbrukinase capsule is effective in re-lieving the neural functional deficits of patients with acute infarction by reducing cerebral circulation's resistance. It is a safe and effective drug treating cerebral infarction.
Keywords：Cerebral infarctionLumbrukinase capsuleCerebrovascular dynamics index
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)