Expression and clinical significance of CD24 in human gastric carcinoma
WANG Rui-hai
Abstract：Objective To study the expression and clinical significance of CD24 in human gastric carcino-ma. Methods The expression of CD24 in the gastric carcinoma (n =46), superficial gastritis (n =28) , atrophic gastritis (n =35), intestinal metaplasia (n = 42) and peritumoral tissue(n=25) were detected by immunohisto-chemistry method. Results The positive expression of CD24 in gastric carcinoma, peritumoral tissue and intestinal metaplasia were significantly higher than those in superficial gastritis and atroph gastritis (P <0. 01) ; and the posi-tive expression of CD24 in gastric carcinoma was higher with the rise of TNM staging(P <0.01), the extent of infil-tration was aggravated with the severity (P <0.01) , in existing lymph node metastasis was notably higher than those in non-existing lymph node metastasis (P <0.01). Conclusions CD24 may play an important role in the growth of gastric cancer, malignant progression, invasion and metastasis.
Keywords：Stomach neoplasmsAntigenCD24Immunohistochemistry
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)