The effect of Tongyanzhie prescription on the expression of apoptosis genes in rat with cerebral ischemia
CUI Rui-ting
Abstract：Objective To approach the effect and possible mechanism of Tongyanzhie prescription on rat focal cerebral infarct injury. Methods Totally 48 cases of male Wistar rats were randomly divided into sham-operation group, model group, Tongyanzhie prescription low, medium, and high dose group and Nimodipine group. Operative model was made in each group except sham-operation group. Drugs were given 7 days before operation. The expression of Bcl-2 and Bax was evaluated. Results The levels of Bcl-2 and Bax in the six groups were (2. 175 ±0.311)ng/L and (1.950 ±0.245)ag/L,(9.175 ±0.320)ng/L and (5.737 ±0.297)ag/L, (8.913 ±0.331)ng/L and (5.763 ± 0.354 ) ng/L, ( 8.050 ± 0.288 ) ng/L and (5.987 ± 0.331) ng/L, ( 6.913 ± 0.348) ng/L and(6.913 ± 0.402 ) ng/L, (7.025 ± 0.230 ) ng/L and ( 7.125 ± 0.406 ) ng/L, respectively. Compared with sham-operation group, other five groups showed a higher expression of Bcl-2 and Bax( P ＜0. 01 ). Compared with the model group, the expression of Bax of other four groups expressed significantly lower( P ＜ 0.01 ). The Bcl-2 level was obviously higher in the high dose group and Nimodipine group. Conclusions Tongyanzhie prescription alleviates the focal cerebral infarction injury in rats. The possible mechanism may be related to the termination and reversion of neuron apoptosis in ischemic cerebral injury.
Keywords：Focal cerebral infarctionTongyanzhi'e prescriptionApoptosis genesRat
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)