Immunophenotype for prognosis in acute myeloid leukemia
SUN Zhan-chao
PENG Zhi-gang
LAI Yong-rong
LUO Jun
MA Jie
Abstract：Objective To investigate the relation between Immunophenotype and prognosis in acute myeloid leukemia(AML)patients.Methods The expression of Immunophenotype was detected by the flow cytometric in 67 patients with AML treated in the Department of Hematology in the First Mffiliated HospitaI of Guangxi Medical University from Sep of 2003 t0 Mar of 2006.All cases were treated with standardized therapy.The effect was evaluated.Results Thirty-eight cases were complete remission and the complete recovery(CR)rate was 56.7%.The CR rates were not statistically significant(P＞ 0.05)between patients with CD7+,CD19+,CD5+,CD10+ and those with CD7-,CD19-,CD5-,CD10-.Furthermore,the CR rates of patients with lymphoid antigen-was higher than that of patients with lymphoid antigen+(65.3%vs 33.3%,P＜0.05).Conclusions In AML,patients with high express of CD34+,HLA-DR+would get poor possibility in prognosis.Also patients with CD5+,CD7+,CD10+,CD19+,CD20+have poor reaction to chemotherapeutics and have unfavorable prognosis.
Keywords：Acute myeloid leukemiaImmunophenotypePrognosis
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)