The study of c-reactive proteIin, fibrinagen and prealbumin level in patients of acute exacerbation of COPD
LIU Tong-shang
GUO Cai-hong
LUO Xiang-jun
LI Fang-fang
DING Ling-zhi
Abstract：Objective To investigate the changes of serum C-reactive protein (CRP), prealbumin(PA) and fibrinogen(Fbg) in patients of acute exacerbation of COPD(AECOPD).Methods The serum C-reactive protein,fibrinogen and prealbumin level were detected in 30 patients of AECOPD and COPD respectively and in 30 controls,meanwhile, their FEV1% and PaO2 also be measured.Results The serum CRP and Fbg level were apparently higher in the patients of both COPD and AECOPD than those in the controls (F=151.61 and 70.45 respectively,P＜0.05 ;q = 22.40, 8.30, 16.72 and 7.12 respectively, P ＜0.05) ;while the PA level was lower in the patients of both AECOPD and COPD than that in the controls(F = 33.83, P ＜ 0.05, q = 15.26 and 6.31, P ＜0.05).After treatment, the serum CRP and Fbg level in patients of AECOPD was significantly lower(q = 20.06 and 9.61 respectively, P ＜0.05) ; while the PA level was higher(q = 10.35, P ＜0.05).The serum CRP and Fbg level was negatively related with the FEV1% (r = - 0.73 and - 0.82 respectively, P ＜ 0.01).While the PA level was positively related with FEV1% (r = 0.62, P ＜ 0.05).The serum CRP and Fbg level was negatively related with PaO2 (r = -0.81 and -0.68 respectively, P＜ 0.01).While the PA level was positively related with PaO2 (r = 0.71, P＜0.05).Conclusions The detection of serum CRP, Fbg and PA level may be useful for the diagnosis and treatment of patients of AECOPD.
Keywords：Lung diseaseObstructiveC-reactive proteinFibrinogenPrealbumin
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)