Stereotactic radiotherapy followed by gemcitabine for elderly patients with advanced non-small cell lung cancer
ZHANG Jun-qing
WU Tie-ying
WU Zhi-gang
FENG Yan-guo
Abstract：Objective To study the toxicity and efficacy of sequential Stereotactic radiotherapy and gemcitabine for elderly patients with advanced non-small cell lung cancer.Methods Forty-six elderly patients pathologically diagnosed as suffering from NSCLC received stereotactic radiotherapy by a gamma-knife.A stereotactic body frame for exact tumor localization, low speed computed tomography simulation and three dimensional conformal radiotherapy planning were used for whole body gamma-knife treatment.Chemotherapy consisted of single gemcitabine 1000 mg/m2 on days 1 and 8 was given three or four weeks after radiotherapy, average follow time was eighteen months.Results Forty-six patients received stereotactic radiotherapy, forty-four patients received four cycles chemotherapy, and two patients received two cycles chemotherapy due to fourth class thrombocytopenia.Complete remission, partial remission, SD and PD rate was 4.35% (2 cases), 65.2% (30 cases), 17.4% (8 cases) and 13.0% (6 cases) respectively.Time to progress was 7.7 months, median survival time was 12.6 months.One year survival rate was 56%.No grade 3 and 4 pneumonitis occurred and only two patients experience grade 3 esophagitis.Conclusions Stereotactic radiotherapy followed by gemcitabine improves local control rate, shortens time to progress and overall survival time.Its adverse effects aretolerable.
Keywords：Non-small cell lung cancerStereotactic radiotherapyGemcitabine
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)