Analyses of clinical application of statin drugs in cadres
CHEN Shu-yan
WANG Yan
CAO Qing
GU Ye
YANG Dan-ying
SHI Jin-ying
WANG Ye
MA Chan-juan
JIANG Xue-mei
Abstract：Objective To evaluate the statin use among cadres in primary and secondary prevention of coronary heart disease and analyse the potential cause of the difference with the current guidelines.Methods From August to October 2009, 767 cases were randomly enrolled in this research.Clinical data including past medical history, cardiovascular risk factors, and laboratory tests were collected.Risk stratification was determined based on the 2007 Guide to China lipid control.The use of statin and the difference between the guideline was observed.Logistic regression analysis was used to identify the potential cause.Results Totally 68.08% of cases were at high and very high risk of cardiovascular disease.The rate of statin use among such patient population was 41.67%.However, 259 patients with indications for statin were not on drug use, which accounted for 58.33% of the studied subjects.The main cause of statin underuse was due to non-prescription by physicians, which accounted for 43.47% of all causes.Logistic regression analysis suggested that statin prescription was significantly associated with age, coronary revascularization and peripheral artery atheresclerosis (P ＜0.05).Conclusions There is a big gap between current clinical practice and application of guidelines in statin treatment.Clinical doctor as a key factor point should learn more about the guideline and advocate to patients.
Keywords：StatinCoronary heart diseaseSerum lipidsRisk stratification
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)