A study of experiment TGF-β1 the left to right flow of congenital heart disease
GUO Jun-xiao
LIU Zhi-ping
Abstract：Objective To investigate the relationship between development pulmonary hypertension (PH)and TGF-β1 in the congenital heart disease(CHD) and PH patients.Methods Serum of vain TGF-β1 concentration of CHD was measured by ELISE assy in different pulmonary hypertension and time (among the non-PH group and mild,moderate and servere PH groups every 12).Results There were significant changes in serum levels of TGF-β1 at the different PH.in the non-PH and mild, moderate PH, there were significant difference between the non-PH and mild,moderate PH and servere PH groups levels of TGF-β1 , especially, there is a noteable change between the non-PH and servere PH groups (P＜0.01).Conclusions TGF-β1 in the left to right flow CHD patient has a great effect on the shaping and development of PH, and check the factor concentration may estimate the PH level of the CHD, operation standard and prognosis.
Keywords：Left to right flowCongenital heart diseaseTransforming growth factor-β1
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)