Therapeutic effects of continuous renal replacement therapy on tumor necrosis factor-α and interleukin-6 in treatment of multiple organ dysfunction syndrome
YANG Mei
XING Lin
Abstract：Objective To study the impact of continuous renal replacement therapy(CRRT) on tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in multiple organ dysfunction syndrome(MODS).Methods Forty patients with MODS were divided randomly into the CRRT group (therapeutic group,19 patients) and non-CRRT group(contrast greup,21 patients).Both groups were treated with conventional therapies.Organ function recovery time,tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels were also detected on the first day and seventh day of admission.Results The recovery time of organ function was significantly decreased compared with that of the contrast group.The TNF-α and IL-6 detected at the end after CRRT were decreased significantly compared with those in the contrast group[TNF-α:(115.0±27.8) ng/L vs (78.6±35.6) ng/L;IL-6 (86.5±23.3) ng/L vs (122.7±28.6)ng/L].Conclusions The result shows that the TNF-α and IL-6 is overproduced during the development of MODS and can be removed effectively by means of CRRT.CRRT has a good therapeutic effect on MODS.
Keywords：Continuous renal replacement therapyMultiple organ dysfunction syndromeTumor necrosis factorInterleukin-6
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)