Autologous bone marrow stem cell intrahepatic transplantation for treatment of decompeusated liver cirrhosis
OUYANG Shi
CHENG Tao
LI Zhuo-liang
LIU Shu-ren
XIAO Bi
TONG Ming-hua
YU Zhou-yao
KONG Xiang-ping
Abstract：Objective To evaluate the effect of autologous bone marrow-derived stem cell (BMSCs) trans-plantation in the treatment of decomponsated hepatic cirrhosis. Methods Bone marrow was harvested (60～100 ml) from 23 patients in the transplantation group. The BMSCs were isolated and infused into liver of patients via he-patic artery. At different time points after the transplantation,the patients'liver function and the quantity of blood platelet (PLT)were evaluated. Results All the serum biochemical indexes remained stable 1 week after the trans-plantation. After 4 weeks, albumin level increased significantly in comparison with the preoperative level(P<0.01) and ALT was significantly lowered (P<0.01), but total hilirubin and the quantity of PLT remained unchanged(P> 0.05). 4 weeks after transplantation, ascites decreased in 12 cases(52%), appetite improved in 10 cases(43%) and abdomen distention ameliorated in 9 cases (39.1%). No adverse events developed in 23 patients with bone marrow stem cells transplantation. Conclusion BMSCs transplantation can improve the liver function of patients with decompensated liver cirrhosis and showes good safety and effectiveness.
Keywords：Hepatic cirrhosisBone marrow stem cellTransplantation
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 333-334 )