The adverse effects of diabetic ketosis on heart in young and middle-aged patients
ZHANG Qiu-mei
YU De-min
LI Jin-jin
LI Jing
LI Chun-jun
Abstract：Objective To observe the changes of myocardial enzymogram and myocardial damage during diabetic ketosis (DK)or diabetic ketoacidosis(DKA) in young and middle-aged patients. Methods Seventy-eight hospitalized patients (45 male and 33 female) of DKA were recruited. Myocardial enzymogram which included crea-tine phosphokinase (CK), creatine phosphokinase isoenzyme (CK-MB) and aspart aminotransferases (AST) was measured on admission at ketosis stage and on 7 days after ketosis recovery. Electrocardiographs were also performed and compared during those two stages. Results Seventy-eight hospitalized patients with DK or DKA had signifi-cantly higher levels of myocardial enzymogramCK, CK-MB and AST at ketosis stage than those in stable stage. The changes of ECG were found in 46 cases (58.9%)of all the patients. The highest morbidity of ECG abnormality was ST-T change which was found in 32 cases(41.0%), ST segment depression in 8 cases, ST segment height in 1 case, T wave flat or inversion in 23 cases, sinus tachycardia in 18 cases (23.1%). 32 of 46 cases with abnormal ECG improved on 7th day with ketosis recovery, furthermore,20 cases fully recovered. The levels of CK, CK-MB and AST with abnormal ECG in acute stage were significantly higher than those with normal ECG. 3 patients had severe ketoacidesis, minute elevations of myocardial biomarkers showed 2 folds above reference value. ST segment showed depression of 0.1 mV in 2 cases and ST segment elevated in 1 case. The high levels of CK, CK-Mb and AST and changes of ECG restored in the stable stage. T segment restored 0.05 mV in 2 patient with ST segment depression and ST segment elevation in 1 case restored to normal also. Conclusions Diabetic ketoacidosis has a nonspecific myocardial injury. The myocardial changes should be monitored and effective protective therapy should be taken during ketosis episode.
Keywords：Diabetic ketosisMyocardial enzymeElectrocardiogram
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 325-327 )