The effect of different courses of intensive insulin therapy on protection of pancreatic β-cell function in oral hypoglycemic agents failed diabetes
YE Li-hong
TAN Jie
XU Xiao-hua
SUN Liao
Abstract：Objective To evaluate the effect of different courses of intensive insulin therapy on protection of pancreatic β-cell function in oral hypoglycemic agent failed type 2 diabetes (T2DM). Methods According to cour-ses of intensive insulin therapy, 64 patients with OHA failed T2DM were divided into group A(20 cases,10 days), group B (22 cases, 30 days)and group C (22 cases, 60 days). Results At the end of different courses, the daily administration of basic dose and premeal supplementary dose of insulin at target blood glucose level in group B and C were lower than group A. The average dose of total daily insulin in group C was significantly lower than that in group A. The insulin secretion and C-peptide secretion was significantly improved in group B and C. Glycosylated hemo-globin decreased in all groups, most significantly in group C(P<0.05). After 1 year, blood glucose level was ef-fectively controlled by oral hypoglycemic agents alone in 61% cases of group B and 68% of group C. Conclusion Sixty days of intensive insulin therapy is effective to recover β-cell function in with OHA failed T2DM patients.
Keywords：DiabetesType 2Intensive insulin therapyOral hypoglycemic agentsPancreatic β-cell
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 323-324 )