Analysis and prevention of adverse reaction of anti-tuberculosis drugs in elderly patients
WANG Xiu-li
ZHANG Le-ping
WANG Yuan-hong
Abstract：Objective To observe therapeutic effect of tuberculosis in elderly patients. Methods One hundred and eighty-six elderly patients(> 60 years old) and one hundred and nighty-eight patients (20-60 years old) were observed. Adverse drug reactions and methods of preventing adverse drug reactions during the treatment with anti-tuberculosis drug were analyzed. Results Adverse reaction rate in elderly patients was 62% (115 cases) and 32% (58 cases) in 20-60 years' old patients. Among elderly patients, 53 cases had adverse reactions in 15 days after treatment started, 28 cases between 15 and 30 days, 14 cases between 1 to 2 months, and 14 cases in o-ver 2 months. Thirty-two cases among 20-60 years' old patients got adverse reactions in 15 days, and 18 cases be-tween 15 to 30 days, 10 cases between 1 to 2 months, and 8 cases over 2 months. Conclusions Adverse reaction occurs earlier and more frequently in elderly patients than that in young and middle-aged patients. An reasonable chemotherapeutic plan and proper dosage of chemotherapy drugs can reduce adverse reactions and accomplish the courses of anti-tuberculosis treatment.
Keywords：Pulmonary tuberculosisElderly patientsAdverse drug reaction
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 223-224 )