Effect of Aprotinin on C-Jun NH_2 terminal kinases signaling pathway in rats of brain ischemia-reperfusion
JIANG Cheng-ping
WANG Xiao-ming
WU Bi-hua
Abstract：Objectives To study the effect of Aprotinin on C-Jun NH_2 terminal kinases signaling pathway in mrs of brain ischemia/reperfusion. Methods Healthy rats were randomly divided into 3 group: sham operated group, model group and Aprotinin group. The brain tissue were removed, embedded and sliced up. The p-JNK was detected by immunohistochemistry and TUNEL in the hippocampal CA1 region was counted. Results The p-JNK in model group was significantly expressed (239.17±2.74). The level of p-JNK in Aprotinin group (176.53±0.36) was much lower than that in model group (P <0.05). In Aprotinin group, the apoptotic index (27.06±3.16) was much lower than that in model group (62.13±1.04) (P<0.05). Conclusions In the process of brain ischemia/reperfusion injury, JNK signaling pathway plays an important role. Aprotinin may help protect neurons against apop-tosis by inhibiting of JNK signaling pathway.
Keywords：Ischemia-reperfusion injuryAprotininBrainC-Jun NH_2 terminal kinasesSignaling pathwayRats
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 215-216 )