Obesity and cigarette smoking impaired arterial stiffness with oxidative stress
OUYANG Chi
CHEN Xiao-lan
MO Yan-xiu
TANG Yin-juan
LI Shi-wang
LIU Ke-feng
Abstract：Objective To investigate the effect of obesity and cigarette smoking on arterial stiffness with ox-idative stress. Methods Eighty five healthy male students were divided into two groups according to BMI or waist circumference. Group A was control group(n=41), group B was obese group(n =44) which was given cigarette smoking for 25 days. Then, arterial stiffness, plasma malonaldehyde(MDA) and uric acid(UA) levels of each sub-ject in group A, pre-and post-cigarette smoking of group B were analyzed. Results The arterial stiffness (1.78±0.26 vs 1.97±0.38, P <0.05), plasma MDA(3.88±1.13 vs 4.32±1.56, P<0.05) and UA(295±43 vs 361 ± 57, P < 0.05) levels were significance higher in pre-cigarette smoking of group B compared with group A. The arterial compliance was significance lower(1.97±0.38 vs 1.54±0.32, P <0.01) and the plasma UA level(295±43 vs 472±39, P <0.01) was significance higher in post-cigarette smoking of group B than that in other groups.Conclusions The plasma MDA and UA levels increased, which were product of oxidative stress. These indicated that the disorder of oxidation-antioxidation impaired arterial stiffness and arterial compliance, also exacerbated the morbidity and mortality of cardiovascular disease in obesity and cigarette smoking.
Keywords：ObesityCigarette smokingArterial stiffnessOxidative stress
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 199-200 )