Expression anti clinical significance of cyclooxygenase-2 in cervical intraepitheliul neoplasia and cervical cancer
HAN Li-li
WANG Chun-hong
WAN Ying-jun
Abstract：Objective To study the expression and clinical significance of cyclooxygenase(COX)-2 in cer-vical intraepithelial neoplasia(CIN) and cervical cancer. Methods The expression of COX-2 in the cervical cancer (n=45), CIN (n=25) and normal cervical tissue (n=20) were detected by immunohistochemistry method. Results The positive rate of COX-2 in cervical cancer were 82.2% (37/45), 44.0% (11/25) in CIN and no expression in normal cervical tissue. Showing no significant difference among 3 groups(P <0.01). The positive rate of COX-2 in G_1 -class were significantly higher than that in G_2, G_3-class (P < 0.05). The positive rate of COX-2 in existing lymph node metastasis was significantly higher than that in non-existing lymph node metastasis(P < 0.05) but showed no significant relation with the tumor size, type of histological and stage of FIGO (P > 0.05). Conclusion The over-expression of COX-2 may be involved in occurrence and development of cervical cancer.
Keywords：Cervical cancerCyclooxygenase-2Immunohistochemistry
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 162-163 )